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KMID : 1034320160070020043
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Sleep Medicine Research
2016 Volume.7 No. 2 p.43 ~ p.47
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Narcolepsy: Association with H1N1 Infection and Vaccination
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Song Ji-Hyun
Kim Tae-Won
Um Yoo-Hyun
Hong Seung-Chul
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Abstract
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Epidemiological studies have demonstrated an association between H1N1 influenza infection and vaccinations. This article reviews the various studies, and suggests the biological mechanisms explaining why and how H1N1 influenza infection or vaccine stimulates the autoimmune response, thereby resulting in narcolepsy. Among the vaccines, the effect of Pandemrix was scrutinized more than other vaccines, due to its higher association with an increase of narcolepsy onset. The consequences of using other vaccines which contain same or different adjuvants as Pandemrix, were also analyzed.
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KEYWORD
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Narcolepsy, Influenza, H1N1, Vaccine
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